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During the second half of the 16th century, the Portuguese Crown entered a succession crisis with the loss of the young heirless king, Dom Sebastião, at the battle of "Alcacér-Quibir". As a result of the crisis, the Portuguese nobility keen to avoid a civil war, reluctantly agreed to unify Portugal with Spain under the crown of King Phillip II, thus creating the period of "Iberian Union" which lasted from 1580 to 1640. During the union period, the Portuguese Empire interests were negatively affected, because of the rivalry between Spain and England, as well as Madrid's disinterest in Portugal's overseas matters. Furthermore, much of Portugal's overseas maritime/naval capacity and resources were disrupted with the commissioning and redirection of its vessels towards the Great Armada preparations for the invasion of Britain, which had disastrous consequences for Spain and Portugal. By then, as a result of the belligerence, the Treaty of Windsor had been suspended, while at the same time the Netherlands seized the opportunity to gain footholds in Portuguese Empire territories of South America, Africa and Far East.

Portugal regained its independence from Spain in 1640, and to re-enforce its world position, the wedding of the British King Charles II to Princess Catherine of Bragança was celebrated. However, despite Portugal regaining most of the territories previously lost to the Netherlands, this royal wedding marked the beginning of a slow decline in Portugal's scientific eminence and domination of world affairs. The expulsion of the remaining unconverted Jewish community also played an important role in this decline. Nevertheless, at the end of the 17th century, a period of stabilisation followed and gained momentum during early 18th century, after the discovery of large deposits of gold and diamonds in Brazil. As a result of the new wealth flowing into the national treasury, the Portuguese Crown was able to finance many major projects to develop and modernise the country and some overseas possessions.

Amidst this new period of rejuvenation, in 1755, on the 1st of November, the Great Lisbon Earthquake and subsequent tsunami devastated the Portuguese Empire's capital. The effects were such that victims were recorded as far afield as Morocco. Of the estimated more than 200,000 Lisbon inhabitants, at least some 40,000 perished. Between the initial quake (estimated to be of around 8.5 degrees) and subsequent aftershocks, flooding and fires, about 60% of all buildings and structures were lost together with art, archives, libraries, factories, businesses, etc. The national GDP dropped an estimated 40%, marking the start of another national crisis compounded by the expelling of the Jesuit and other religious orders and with it many academics and scientists of the day.

At the beginning of the 19th century, as a result of Flirty Braidy FlipFlops q4ZeALvx
and expansion conflicting with the British Empire and their allies, the country was invaded by Napoleon's army, throwing the Portuguese monarchy and rest of the country into chaos at all social and economic levels. The Royal Family and most of the nobility left Lisbon and settled in Wembley Textured Mens Thong Flip Flops g6eivykHg
, in self-imposed exile. Even after the Peninsular War ended in defeat for the French, the country nevertheless failed to recover and went from crisis to crisis almost continually until the beginning of the 20th century, with the loss of Brazil in 1822 and the scramble for Africa in the 1880s severely curtailing the Portuguese Empire's size and power.

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Harry—who had just recently returned from a weekend trip to Lesotho—gave brief remarks at the event, in his role as Commonwealth youth ambassador, and incorporated some of that standard Harry wryness. “I guess you can say you’re stuck with me,” he joked, continuing, “I, together with my wife, Meghan, look forward to convening young people from around the Commonwealth to hear your ideas, work with you to build platforms for you to collaborate and form partnerships, and continue to meet with many of you as we travel around in our work on behalf of the royal family.”

Meanwhile, we now wait for Beckham to hopefully post a selfie with Meghan and Harry (with the Queen peering in curiously from the corner) by night’s end.

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Photos:
1 / 12
The Whisper. Pictured here at the Invictus Games, Harry has a secret for one person only. (Meghan Markle is that one person, if it wasn’t abundantly clear from the photograph.)
The Quick Peck. Still pre-engagement at this point, these two look like college students at a late-night frat party (uh, in the most glamorous sense).
The Double Hand-Hold. For their official engagement announcement, Markle clutched Harry with both hands, positioned for her ring to be on full display.
The Resilient Hand-Hold. No obstacle—no poles, metaphorical or literal—are going to get in the way of their love.
The Bag Raise. Here, Markle and Harry demonstrate how to take care of business (fix hair, check blazer pocket, easily wield a handbag) all while, yes, holding hands.
The Shoulder Pat. Perhaps understanding the challenges of having to make brief small talk with throngs of supporters, Harry checks in, affectionately, to see how his fiancée is doing.
The Sometimes the focus is going to be on just one of the two, and both of them instinctively know when to let attention fall on the other—as Harry does here.
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Josh Duboff is a VF.com senior writer, based in New York, who covers entertainment and culture.
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Article Text

Original Article
Famciclovir for ophthalmic zoster: a randomised aciclovir controlled study

Abstract

AIMS To compare the efficacy and safety of famciclovir with aciclovir for the treatment of ophthalmic zoster.

METHODS Randomised, double masked, aciclovir controlled, parallel group in 87 centres worldwide including 454 patients with ophthalmic zoster of trigeminal nerve (V) comprised the intent to treat population. Oral famciclovir 500 mg three times daily or oral aciclovir 800 mg five times daily for 7 days. Assessments included day 0 (screening), days 3 and 7 (during treatment), days 10, 14, 21, 28 and monthly thereafter, up to 6 months (follow up). Proportion of patients who experienced ocular manifestations, severe manifestations and non-severe manifestations; loss of visual acuity was the main outcome measure.

RESULTS The percentage of patients who experienced one or more ocular manifestations was similar for famciclovir (142/245, 58.0%) and aciclovir (114/196, 58.2%) recipients, with no significant difference between groups (OR 0.99; 95% CI 0.68, 1.45). The percentage of patients who experienced and manifestations was similar between groups, with no significant difference. The prevalence of individual ocular manifestations was comparable between groups. There was no significant difference between groups for visual acuity loss.

CONCLUSION Famciclovir 500 mg three times daily was well tolerated and demonstrated efficacy similar to aciclovir 800 mg five times daily.

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In 50%–72% of patients with ophthalmic herpes zoster (HZO), involvement of the ocular structures leads to ocular manifestations ranging from self limited processes to chronic ocular inflammation or neuropathy which may lead to visual loss. MRL420v2 New Balance Classics OKpiyCAbZ6
The mechanism of ocular manifestations is thought to include active viral replication within the eye and ophthalmic trigeminal nerve, followed by vascular and neural inflammation and damage.

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